This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 29 November - 5 December 2025 and includes updates on respiratory virus epidemiology in the EU/EEA, chikungunya, West Nile virus, Marburg virus disease, Influenza A(H5N2), HIV/AIDS surveillance, Ebola, Middle East Respiratory virus (MERS), shigellosis Cabo Verde.